CD4 and Hypertension: Similar to our previous studies [8], we showed that miPEP31 was endogenously expressed in hypertension-related tissues, such as the aorta, perivascular adipose tissue (PVAT), kidney, heart and spleen of wild-type (WT) mice (Fig. 1A), and cells, including mouse cardiac fibroblasts (MCF), mouse aortic vascular smooth muscle cells (MOVAS) (Fig. 1B), immune cells, naïve CD4+ T cells, activated CD4+ T cells, and iTregs (induced regulatory T cells) (Fig. 1C), by using a polyclonal antibody against miPEP31 (Fig. S1A).