Because most CPEB2-knockout (KO) mice die within 3 days after birth due to respiratory failure [40, 41], the SC-CA1 circuit was only investigated in CPEB2-conditional KO (cKOCamk2) mice whose Cpeb2 was ablated in postsynaptic CA1 but not presynaptic CA3 neurons [35]. The gene discussed is CPEB2; the disease is respiratory failure.