NES and Cognitive impairment: To assess whether CPEB2-cKONes mice exhibited cognitive impairment, we conducted behavioral assays previously used in CPEB2-cKOCamk2 mice, which showed defective consolidation of spatial memory in the Morris water maze test and fear memory after contextual fear conditioning [35], but excluded the fear conditioning test because hemizygous Nestin-Cre mice showed defective contextual- and cued-conditioned fear [45].