However, one reason why SHIP1 expression was increased, particularly in the ETV6-RUNX1-ALL, could be that the fusion with RUNX1 prevented the ETV6 transcription factor from binding to the Ets binding site in the INPP5D locus, thus abolishing the ETV6-mediated repression of SHIP1 expression (Fig. 8A). Here, INPP5D is linked to acute lymphoblastic leukemia.