We analysed the gene expression of INPP5D and additional important phosphatases and kinases of the AKT and RAS signaling pathway in different subtypes of B-ALL using transcriptome data of 1,639 B-ALL patient samples (Fig. 1) [http://www.stjuderesearch.org/data]. The gene discussed is INPP5D; the disease is precursor B-cell acute lymphoblastic leukemia.