On the other hand, seven genes (DNAJB11, HAO2, MBL2, THRSP, BHMT, CRYL1, and IGFALS) were downregulated in the hepatotoxicity pathway, two genes (MCM10 and LGR5) in necrosis, four genes in phospholipidosis (FABP1, SLC2A3, HPN, and SERPINA3), one each in hepatocarcinogenicity (BTG2) and cholestasis (SLC51A) pathways. This evidence concerns the gene LGR5 and cholestasis.