As shown in Fig. 2H, IGF2BP3 was primarily found in the cytoplasm of HCC tissues, and its expression was significantly higher in cancer specimens than in peri-tumor tissues. Of 118 samples, 59 (50%) showed positive expression of IGF2BP3, whereas the respective peri-tumor tissues did not express IGF2BP3 (P < 0.001; Fig 2I). The gene discussed is IGF2BP3; the disease is cancer.