We then analyzed the expression level of representative proteasome subunits and WEE family kinases in patients of 17 cancer types from The Cancer Genome Atlas (TCGA).44 As shown, the mean expression level of a subset of proteasome subunit genes, including 20S core subunits (α1–7, β1–7) and 19S regulatory subunits (PSMC1–6), was significantly upregulated in various human malignancies (15/17, Supplementary Fig. 6e), compared with their normal counterparts. Here, PSMC1 is linked to cancer.