AMPD2 and Fanconi renotubular syndrome: In contrast, the activation of AMPD2 by much lower amounts of fructose, functionally contributes to a much greater pathology characterized by metabolic dysregulation and energy imbalance with low mobilization of energy stores (glycogen and fat), inflammation, Fanconi syndrome, nutrient loss (glucose, amino acids and phosphate) in the urine and failure to thrive/growth retardation.