MYCN and acute myeloid leukemia: In addition, Runx1t1 was identified as one of only 6 transcription factors necessary to reprogram committed murine blood cells to hematopoietic stem cells67, while a recent study in acute myeloid leukemia (AML) demonstrated that both Mycn and Runx1t1 were able to reprogram multipotent progenitor cells and overcome self-renewal limiting capacity, which in turn led to AML transformation in cells that had lost JARID2, a component of PRC2 and a tumor suppressor68.