Furthermore, the critical role of PRC2 in embryonal development is demonstrated by mouse knockouts of the core components of this complex (Ezh2, Eed, and Suz12), which are all embryonic lethal51, while a CRISPR-Cas9 screen performed in MYCN-amplified neuroblastoma cells demonstrated a top dependency on EZH2, EED, and SUZ1243. Here, MYCN is linked to neuroblastoma.