Our RNAseq data showed NTRK1 to be one of the most highly upregulated genes following shRNA-mediated silencing of RUNX1T1. The RUNX1T1 Y534H mutation led to reduced interaction with HAND2 further suggesting that HAND2 recruits RUNX1T1 to a co-repressor complex to maintain an undifferentiated phenotype in neuroblastoma. Here, HAND2 is linked to neuroblastoma.