Two alveolar rhabdomyosarcoma (aRMS) lines, Rh41 and Rh3, which are t(2;13) PAX3-FOXO1 fusion-positive and express high levels of RUNX1T1, demonstrated significantly reduced cell proliferation following shRNA knockdown (Fig. 8d). Here, RUNX1T1 is linked to alveolar rhabdomyosarcoma.