Furthermore, when we included in this analysis RNAseq data of ganglia (Th-MYCN+/+; Runx1t1+/−) and tumor (Th-MYCN+/+; Runx1t1+/+) from our neuroblastoma-prone mice, GSEA showed highly concordant results with the human data, with enrichment of the same top upregulated and downregulated Hallmark gene sets in mouse ganglia carrying only one function Runx1t1 allele (Fig. 8a). The gene discussed is MYCN; the disease is neoplasm.