MYCN and neuroblastoma: Furthermore, examination of human neuroblastoma cell lines showed no significant difference in the mean level of RUNX1T1 RNA expression between MYCN-amplified and non-amplified lines (Fig. 3c), while RUNX1T1 protein levels were markedly higher in those lines with amplified MYCN (Fig. 3d), suggesting that MYCN drives increased RUNX1T1 translation, not transcription.