On the other hand, MYC oncoproteins are known to drive suppression of tumor immunity34,35, and the top upregulated Hallmark gene sets showed enrichment of IL2_STAT5_signaling, TNFA_signaling_via_NFKB and Hypoxia (Fig. 8a), all of which have roles in inflammation and immunity36–38. This evidence concerns the gene TNF and neoplasm.