Although some studies reported that the cancer cells are unresponsive to STING agonism due to epigenetic silencing of the STING gene20,21 or suppression of STING signaling22,23, others indicated that cancer cell STING is required for anti-tumor immune responses induced by radiation therapy and DNA-damaging reagents in preclinical tumor models24,25. Here, STING1 is linked to cancer.