The tumor cell-targeted ADCs also led to robust cytokine induction in the co-cultures of PBMCs and HER2-expressing HCC1954 and NaPi2b-expressing Kuramochi cancer cells (Supplementary Fig. 10a-10d), which, together with the above in vivo and in vitro data, indicates that the activity of the STINGa ADCs is observed in multiple tumor models and tumor antigens. Here, SLC34A2 is linked to neoplasm.