We sought to reconcile the lack of STING activation in cancer cell monocultures (Supplementary Fig. 9d, and e) with the significant anti-tumor activity of the Fc-mutant ADCs in vivo (Fig. 3a) and in vitro (Fig. 3c–e), which was dependent on tumor cell STING (Fig. 3f). The gene discussed is STING1; the disease is cancer.