ERBB2 and cancer: The tumor cell-targeted ADCs also led to robust cytokine induction in the co-cultures of PBMCs and HER2-expressing HCC1954 and NaPi2b-expressing Kuramochi cancer cells (Supplementary Fig. 10a-10d), which, together with the above in vivo and in vitro data, indicates that the activity of the STINGa ADCs is observed in multiple tumor models and tumor antigens.