Interestingly, the Fc-wt but not Fc-mutant HER2-ADC treatment induced cytokine production in SKBR3 and THP1 co-cultures (Supplementary Fig. 9a), indicating that the cancer cell-intrinsic STING is not activated in THP1 cell co-cultures (explored further in the next section). This evidence concerns the gene STING1 and cancer.