STING1 and neoplasm: Indeed, Fc-wt ADC maintained robust killing activity in STING WT cancer cell co-cultures even in the presence of a low number of immune cells (Fig. 3g).The activity in the STING KO cell co-cultures was reduced with decreasing numbers of immune cells (Fig. 3h), highlighting the important contributions of tumor cell-intrinsic STING to the anti-tumor activity of the ADCs, specifically in limiting conditions, such as low doses of ADCs, low antigen expression, or lower numbers of tumor resident FcγRI+ myeloid cells.