STING1 and neoplasm: Both HER2- and NaPi2b-targeted Fc-mutant ADCs elicited notable anti-tumor activity in the SKOV3 (HER2) and OVCAR-3 (NaPi2b) human tumor xenograft models in CB.17 SCID mice (Fig. 3a, b, Supplementary Fig. 8a–8d), which indicates a significant contribution of tumor cell intrinsic STING activation to the anti-tumor activity.