We observed the expected patterns of genomic events in specific diagnoses, including TP53 rearrangements in osteosarcoma, EWSR1 rearrangements in Ewing sarcoma, ALK mutations and MYCN amplification in neuroblastoma, BRAF fusions and IDH1 mutations in low-grade glioma and TP53 mutations, CDKN2A/B deletions and H3F3A mutations in high-grade gliomas. The gene discussed is EWSR1; the disease is central nervous system cancer.