These can limit the infiltration, activation and cytotoxicity of CD8+ T cells by reducing the display of MHC-I molecules on tumor cells9, suppressing IFN signaling10, repressing chemokine production11, altering the composition of the extracellular matrix12, and increasing the expression of co-inhibitory molecules such as PD-L113,14. The gene discussed is CD8A; the disease is neoplasm.