To determine whether Dusp18 inhibition affects T cell-mediated antitumor function, shRNA-mediated inhibition of Dusp18 was performed in MC38 CRC cells and ovalbumin (OVA)-expressing B16 melanoma (B16-OVA) cells (Supplementary Fig. 1g, h). This evidence concerns the gene DUSP18 and colorectal carcinoma.