Finally, taking into consideration the causal associated between ITPKC polymophisms and Kawasaki disease (Onouchi et al., 2008), we have noted that overexpression of ITPKC in lung fibroblasts results in enhanced T cell activation (ORAI1, STIM1), which is associated with Kawasaki disease (Murray et al., 2017). Here, ITPKC is linked to Kawasaki disease.