Loss of Fbxl4 phenotypically mirrors Pptc7 KO in mice (Niemi et al, 2019; Alsina et al, 2020), and PPTC7 and FBXL4 have significant and positively correlated essentiality profiles across over one-thousand cancer cell lines (Fig S2A, [Dempster et al, 2019Preprint]). This evidence concerns the gene FBXL4 and cancer.