Furthermore, among the 19 TFs that were DE with the knockdown of SH3PXD2B, we observed downregulation of not only PPARG,90 but also of a fatty acid master TF, SREBF191 and the TF TBX15, which we previously identified as a master trans regulator of abdominal obesity genes.19 The gene discussed is PPARG; the disease is Abdominal obesity.