DGAT2 and obesity due to melanocortin 4 receptor deficiency: We first observed that DGAT2 is highly expressed in the adipose tissue when compared to the liver (Fig. 7a–c), with significantly higher adipose expression (p-value = 4.23 × 10−4 by the Wilcoxon rank sum test) in the females (n = 182) than males (n = 80) with obesity.