Overall, previous mouse studies found evidence of obesity traits for 8 of the 17 genes that include AHNAK,87LHCGR,105NF1,106PDC6IP,107PPP2R5A,102SH3PXD2B,72,73SNX10,108 and TSC22D1. 109Additionally, PDE8B has previously been associated with monogenic syndromic obesity in humans.110. Here, PDE8B is linked to obesity due to melanocortin 4 receptor deficiency.