PTGS2 and gout: However,NSAIDs have been widely used in clinical practice for the treatmentof gouty arthritis.67 Prolonged use ofmefenamic acid and other cyclooxygenase-2 (COX-2) inhibitors are oftenassociated with gastrointestinal (ulcers, intestinal villous atrophy,diarrhea, and bleeding) and cardiovascular issues.68 Because of this, the search for a safer and more effectivetherapeutic alternative is still necessary.