NETsis a key mechanism for clearance and inflammation resolution in gout.20 NETosis-deficient mice exhibited exacerbatedand chronic inflammation after monosodium urate (MSU) crystal injection.21 Conversely, another study revealed that neutrophilactivation in MSU-induced gout did not interfere with resolution butled to an increase in MPO activity in the paws of mice.22 The gene discussed is MPO; the disease is gout.