ATIC and cystic fibrosis: These known factors contributed to diverse, well-described pathogenesis functions in CF and other diseases, comprising cellular metabolism (arcR [68], purR [69], purH [70], thyA [71]), biofilm formation (nreC [72], yycI [73]) and other adhesion mechanisms (atl [74], fnbA [75,76], clfA [77]), autolysis (yycI [78], atl [74]), invasins (atl [79], fnbA [75,76]), iron metabolism (sirA [80]), virulence gene regulation (vraS [81], kdpD [82], saeS [83–85], purR [69,86], yjbH [87]), and immune evasion (sdrE [88]).