In addition, there is emerging evidence for a bidirectional link between AD pathology and sleep.18-20 Sleep alterations and obstructive sleep apnoea (OSA) have been associated with amyloid-β and tau pathology in cognitively impaired21-24 and intact subjects.25-34 Sleep alterations are inherent to increasing age, however, patients with AD suffer from more pronounced or distinct sleep disruptions. The gene discussed is MAPT; the disease is Alzheimer disease.