Facilitate genetic testing. Given the genetic basis of NKX2-1-RD, consider incorporating genetic testing, such as NKX2-1 gene sequencing, WES, or Array CGH, into the diagnostic workup of patients with CH, particularly those with associated respiratory distress and/or neurological impairment and/or pituitary deficiency. The gene discussed is NKX2-1; the disease is cyclic hematopoiesis.