Several of the identified pathways and associated genes in this work could be utilised to find suitable drug targets to reduce both preoperative and postoperative fibrosis and indeed several genes are already being investigated to improve the outcome of glaucoma filtration surgery such as the TGF-β pathway, VEGFs, PDGF, MMPs, SPARC and p53 [12, 128, 129]. The gene discussed is SPARC; the disease is glaucoma.