In a model of pulmonary fibrosis, upregulation of CDKN1A and cell cycle arrest was also reported together with myofibroblast activation, telomere shortening and release of inflammatory cytokines pointing to a both senescent and fibrotic condition in which DNA damage causes cell cycle arrest via TP53 (p53) [93]. The gene discussed is TP53; the disease is pulmonary fibrosis.