Utilizing its greater affinity for VEGF-A than VEGFR2 [20], VEGFR1 is able to bind the former to sequester it from interacting with the latter and activating the VEGFR2 pathway [5, 30], the canonical process by which pathological angiogenesis occurs in AMD and DR [5]. The gene discussed is VEGFA; the disease is age-related macular degeneration.