The significant role played by the VEGF family in inflammation, particularly the recruitment of monocytes and leukocytes by VEGFR1 ligands [35], means that rAAV2-sVEGFRv-1 being able to protect against inflammatory cell infiltration by macrophages and leukocytes [22] addresses this influential aspect of angiogenic ocular disorders like AMD and DR. The gene discussed is FLT1; the disease is age-related macular degeneration.