USP36 and type 2 diabetes mellitus: Though DOCK4 has not been directly associated with eGFR in GWAS, it has been associated with several traits related to kidney health, such as diastolic blood pressure, type 2 diabetes, dehydroepiandrosterone sulphate measurement (a marker for adrenal disorders) and “Water consumption (glasses per day).” A recent study demonstrated that in vivo and in vitro DOCK4 expression was found to increase with high-glucose, and that DOCK4 could reverse USP36-induced epithelial-to-mesenchymal transition effect, which is involved in diabetic renal fibrosis and nephropathy [36].