HIF1A and bacterial infectious disease: These gene expression changes were driven by HIF1α activation, identified by GO term analyses (TOPPFUN) (Fig 3D) and Ingenuity Pathway Analysis (IPA) that also revealed enrichment of pathways typically associated with bacterial infections such as ‘Pathogen-induced Cytokine Storm Signalling’, ‘Acute Phase Response Signalling’ and ‘Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses’.