PTPN11 and colorectal carcinoma: Although we did not observe aberrant coexpression of either SHP1 or SHP2, we noted the upregulation of another member in the PTP family, i.e., Ptpn18; upregulation of Ptpn18 has been reported in yet another type of CRC, i.e., early-onset CRC, and such upregulation carries worse prognosis (40).