Previously, a flow cytometry screen of 5 human carcinoma cell lines showed that MDA-PCa-2b and LNCaP (prostate cancer) and MCF-7 (breast cancer) lines express Siglec-XII, whereas MDA-MB-231 (breast cancer) and PC-3 (prostate cancer) do not express it (18). This evidence concerns the gene SIGLEC12 and Familial prostate cancer.