Some studies in populations with noncirrhotic MASLD have identified independent genetic risk factors (PNPLA3, TM6SF2, and MBOAT7)38 and rare pathogenic variants (PNPLA3, TM6SF2, GCKR, and MBOAT7).10,39,40 However, only 1 of these studies developed an HCC prediction model, with relatively low predictive performance (AUC, 0.64; sensitivity, 0.43; specificity, 0.80).10 Furthermore, genetic markers and pathogenic variants are rarely measured during routine clinical visits, making these mostly unusable outside of research settings. The gene discussed is PNPLA3; the disease is hepatocellular carcinoma.