Of note, among the 6 proteins downregulated by NR-S:M in HepG2 cells, 5 of them (MRLP17, MDIG, GIPC1, NAGPA, FAM127A) were statistically and oppositely upregulated in LIHC vs. non-tumoral adjacent tumor (NTAT) (Fig. 7D). Here, RIOX2 is linked to neoplasm.