To prevent acute kidney injury, the patient was prohibited from taking oral ACE-I when he was not well, such as if he had a fever, cold, other infectious diseases, etc. In his clinical course, the combination therapy of AST-120 and ACE-I was effective for his refractory periodic vomiting and hypertension associated with CKD (Fig. 1). The gene discussed is ACE; the disease is hypertensive disorder.