The expression rates of VEGF in tumor tissues of the lipiodol alone group, lipiodol + DOX group, and lipiodol + TRRP@DOX group 7 days postoperatively were 1.70 ± 0.40%, 6.46 ± 0.32%, 4.43 ± 0.32%, and 0.86 ± 0.40%, respectively, indicating that TRRP@DOX could inhibit neovascularization compared to the lipiodol group (P < 0.0001) and the lipiodol + DOX group (P < 0.0001). The gene discussed is VEGFA; the disease is neoplasm.