This advanced concept was validated with a mousemodel, where SPNpro effectively suppressed tumor progression.43 The same team has further expanded this conceptto smart Nano-PROTACs that reprogram the tumor microenvironment forcancer immunotherapy, specifically targeting cyclooxygenase 1/2 (SPNcox)and Src homology-2 domain-containing protein tyrosine phosphatase-2(checkpoint nano-PROTAC-NPRO).198 Theyhave managed to enhance antitumor immunity and decrease immune suppressionin in vivo studies.147,198. This evidence concerns the gene PTGS1 and neoplasm.