To date, PROTACs still face the challengesof absorption, distribution, metabolism, excretion, and toxicity,which results in low bioavailability, limiting their development andapplication.195 In an early effort, Wangand his team synthesized and developed a nanoplatform for gold nanoparticle-basedmultiheaded PROTACs targeting anaplastic lymphoma kinase (ALK), usinglung adenocarcinoma cell lines (NCI-H2228). This evidence concerns the gene ALK and adenocarcinoma.