PNPLA3 and metabolic dysfunction-associated steatotic liver disease: In summary, the research findings demonstrate that thebuildup of PNPLA3 on lipid droplets within the liver is responsiblefor developing steatosis linked to PNPLA3(148M) varian.139 Another strategy to improve NAFLD is to targetthe Keap1/Nrf2 pathway, which regulates the antioxidant response andlipid metabolism in the liver.