PTPN11 and esophageal cancer: It obtainedDC50 values of 6.0 and 2.6 nm in esophageal cancer (KYSE-520)and acute myeloid leukemia (MV-4–11) cells, respectively.109 Compared to the potent SHP2 inhibitor SHP099,SHP2-D26 demonstrated over 30 times greater effectiveness in inhibitingERK (extracellular signal-regulated kinase) phosphorylation and suppressinggrowth in this specific cancer cell.