CD274 and neoplasm: Recent reportshave also been made of a novel PROTAC that usedcarbon dots (CDs) as scaffolds to degrade PD-L1 protein and activatethe STING pathway in tumor cells.46 TheseCD-based PROTACs (CDTACs) can be combined with PD-L1, recruit CRBN,induce PD-L1 ubiquitination, and degrade them by proteasomes.