CD274 and neoplasm: The therapeuticpotential of immunotherapy is evaluated using variousimmune parameters, such as the presence and activation of tumor-infiltratingT cells, PDL1 expression, and tumor mutational burden.21 However, the treatment can lead to a range ofadverse effects, including autoimmune conditions like thyroiditisand inflammatory bowel disease, and potentially life-threatening eventssuch as myocarditis, encephalitis, and hypophysitis.19,22