SOD1 and amyotrophic lateral sclerosis: Our finding of nuclear dysfunction in misexpressed Annexin ALS variants and Annexin A11a knockout studies in fish larvae, has been conducted in neurons ∼28 h after exiting the mitotic cycle.34 We wished to explore whether this signature was translated to mature end stage spinal cord motor neurons of ALS patients harbouring dominant associated Annexin A11 missense variants.