ANXA11 and amyotrophic lateral sclerosis: A recent report identified a childhood onset de novo p.D40I Annexin A11 variant in a patient with oculopharyngeal muscular dystrophy, suggesting pleiotropic effects.19 Interestingly, ocular abnormalities, including significant alterations to saccadic movement, have been identified in ALS patients in multiple studies.38,39 Second, we found that knockdown of AnxB11 in Drosophila developed an age-dependent climbing phenotype.