ANXA11 and amyotrophic lateral sclerosis: Recently, it was identified that axonal LMNB2 localized to mitochondria in cultured Xenopus retinal ganglion cells, in which LMNB2 knockdown disrupted mitochondrial morphology, reduced mitochondrial membrane potential and also impaired lysosome trafficking.49 Investigating potential dysfunction of axonal LMNB2 in Annexin A11-mediated ALS is scope for future studies.