Similarly, axonal Annexin A11 was recently found to act as a tether linking RNA granules (N-terminus) to lysosomes (phospholipid binding C-terminus) in the recent work by Liao and colleagues.23 It was found that C-terminal Annexin A11 ALS associated variants break the tether that joins RNA granules to lysosomes. This evidence concerns the gene ANXA11 and amyotrophic lateral sclerosis.