We compared this to counts from nine healthy controls, five sporadic ALS (sALS) and a further four controls possessing an N-terminal p.R191Q Annexin A11 polymorphism (present in 4.7% age matched controls, rs2229554) to account for common Annexin A11 variation in the background population. The gene discussed is ANXA11; the disease is amyotrophic lateral sclerosis.