Interestingly, a previous study of changes to nuclear lamina invaginations using Lamin B1 in post-mortem motor cortex from C9ORF72 cases did not reveal any pathological association with ALS.35 Even though we did not investigate nuclear invaginations in our study, we similarly did not detect an association of nucleoplasmic Lamin B2 of spinal cord anterior horn cells in C9ORF72 cases. Here, LMNB1 is linked to amyotrophic lateral sclerosis.