ANXA11 and amyotrophic lateral sclerosis: Experimental large-scale functional investigative analyses have yielded direct associations of Annexin A11 with specific ALS implicated pathways, such as disrupted liquid-liquid phase separation22 (LLPS), RNA granule transport via organelles,23 stress granules and calcium dynamics.12,24 Of note, one study found Annexin A11 to act as a molecular tether, linking RNA granules (N-terminus) with the phospholipid membrane of lysosomes (C-terminus), which are axonally trafficked.23