Enhanced TNFSF13B in FP-AS is an interesting finding as it can be addressed therapeutically by the monoclonal antibody belimumab.45,46 Furthermore, our Nanostring findings also show different expression of regulatory genes that play an important role in the regulation of the innate immunity and the complement cascade, like SERPING1 (serine proteinase inhibitor family G member 1), which regulates complement activation and innate immunity like MIF. Here, MIF is linked to aortic stenosis.