Genome-wide association studies (GWAS)have found numerous riskgenes involved in LOAD, including ApoE4, TREM2, ADAM10, and PLD3,providing us a better understanding of the associated pathophysiologicalprocesses.6 Among them, ApoE4 is knownas the strongest risk gene, with individuals carrying copies of itfacing up to 12-fold increased risk of developing AD compared to ApoE4noncarriers. This evidence concerns the gene APOE and Alzheimer disease.