However,H4 neuroglioma cells are not derived from Alzheimer's disease(AD)patients, and the gene editing used to activate ApoE4 in these cellsdoes not fully elucidate the clinical and genetic mechanisms of ApoE4.Additionally, the function of ApoE4 exhibits significantly differenteffects on various cell types, including neurons, microglia, and astrocytes.Consequently, more clinically relevant samples and studies are necessaryto comprehensively understand the role of ApoE4 in AD. Here, APOE is linked to Alzheimer disease.