,37 In PWMR, we found that genetically predicted plasma levels of circulating COL6A3 (as measured by aptamer 11196) were causally associated with increased risk of CAD (Figure 3A); COL6A3 was also significantly positively associated with CAD in the PWAS (p = 5.3x10−8). This evidence concerns the gene COL6A3 and coronary artery disorder.