Luteinizing hormone/follicle-stimulating hormone ratio: In PCOS, with the increase in LH and decrease in FH, there is an increase in the LH/FSH ratio, which was documented to be at an average of 2.3 [8-11, 13-15, 22, 25-27, 33-35, 38]. The gene discussed is BRD2; the disease is polycystic ovary syndrome.