Immunohistochemistry was negative for beta-catenin, cluster of differentiation 34 (CD34), acute myeloid leukemia (AML), signal transducer and activator of transcription 6 (STAT6), S100, SOX 10, CKAE1AE3, special at-rich sequence-binding protein 2 (SATB2), B-cell lymphoma 2 (BCL2), immunoglobulin G4 (IgG4), and cyclin-dependent kinase 4 (CDK4). The gene discussed is CDK4; the disease is acute myeloid leukemia.