For TCGA datasets, the most significant genes were observed in low-grade groups, such as the favorable performance of ABAT, ADCY2, ALDOC, PDE8B, and GALNT13, as well as the unfavorable performance of LDHA, NAMPT, PLOD2, and SAT1, suggesting prognostic prediction performance of these 11 genes in glioma, particularly in low-grade glioma patients. The gene discussed is PDE8B; the disease is central nervous system cancer.