For TCGA datasets, the most significant genes were observed in low-grade groups, such as the favorable performance of ABAT, ADCY2, ALDOC, PDE8B, and GALNT13, as well as the unfavorable performance of LDHA, NAMPT, PLOD2, and SAT1, suggesting prognostic prediction performance of these 11 genes in glioma, particularly in low-grade glioma patients. This evidence concerns the gene ADCY2 and central nervous system cancer.