A total of 213 samples (Table 1) from 182 individuals (n=12 with confirmed primary HLH and degranulation deficiency; n=170 in whom these conditions were excluded or unknown) were assessed with at least one of the assays (K562- or HMBPP-induced expression of CD107a on NK cells or Vγ9Vδ2 T cells, respectively). This evidence concerns the gene LAMP1 and hemophagocytic syndrome.