Arif et al. silenced VDAC1 expression by means of interfering RNA (siRNA) in cancer cells and found that siVDAC1 reduced VDAC1 levels by approximately 90% in lung cancer cells A549 and H358, prostate cancer cells PC-3, colon cancer cells HCT116, glioblastoma U87, hepatocellular carcinoma cells HepG2, and pancreatic cancer cells Panc-1 when the siVDAC1 was only at nanomolar concentrations. This evidence concerns the gene VDAC1 and malignant colon neoplasm.