BRCA1 and ovarian carcinoma: In this study, we tried to establish a cut-off able to discriminate DDP-sensitive and DDP-resistant PDXs; however, the analysis of the ROC curve revealed that the best cut-off (i.e. 24%) was not sufficiently robust to discriminate such response, suggesting that the basal BRCA1 foci score alone may not be an ideal biomarker to predict the DDP response in ovarian carcinomas.