Lõhmussaar et al. established an in vitro tumor model of fallopian tubes and ovarian surface epithelium (OSE) by targeting the mouse Trp53 gene alone or in combination with Brca1, Pten, and Nf1. The mouse fallopian tubes and OSE tissues were dissected, and organoids were constructed using the matrix gel method. Here, TP53 is linked to neoplasm.