Compadre et al. constructed organoids from tumor biopsies or malignant ascites collected from patients with HGSOC by using the matrix gel method and showed that DNA repair protein RAD51 scores of platinum non-responding tumor organoids were significantly higher than those of platinum-responsive tumor organoids, and that the RAD51 foci were a potent marker of response to platinum-based chemotherapy and survival in OC (Compadre et al., 2023). The gene discussed is RAD51; the disease is neoplasm.