3) Based on the organ-like model, we will explore the role of common gynecological cancer-related signaling pathways such as PI3K/AKT/mTOR, p53, Wnt, and NF-κB in the progression of gynecological malignant tumors and drug resistance, so as to strengthen the depth of the research direction. The gene discussed is NFKB1; the disease is female reproductive organ cancer.