The results showed that inhibition of Pten and simultaneous induction of Pik3ca mutation led to the development of in situ cancer and high-grade serous tumors, respectively, reflecting the frequent activation of the PI3K/AKT axis and the impact of activation of the Wnt pathway in HGSC on tumor generation (Maru et al., 2021b). The gene discussed is AKT1; the disease is cancer.