NPHP1 and Renal cyst: This feature might reflect that epithelial cell proliferation was enhanced during renal cyst formation in NPH1 patients and NPHP1-deficient mouse models (Cantani et al., 1986; Luo and Tao, 2018; Li et al., 2021; Garcia et al., 2022; Petzold et al., 2023).