SHBG and metabolic syndrome: In our study, we found that serum SHBG levels remained inversely associated with the risk of incident MetS after mutual adjustment for confounders such as current smoking and drinking status, physical activity level, age, BMI, SBP, TG, eGFR, γ-GGT, HbA1c, LDL-C, and HOMA-IR, whereas the association between TT, LH and incident MetS was lost.