And another prospective population-based study of 702 middle-aged men who did not have MetS or T2DM at baseline revealed that men with TT or calculated FT or SHBG levels in the lower quartile had a severalfold increased risk of developing MetS (odds ratio [OR]=2.3, 95% CI 1.5–3.4; 1.7, 1.2–2.5; and 2.8, 1.9–4.1, respectively) after 11 years of follow-up. This evidence concerns the gene SHBG and type 2 diabetes mellitus.