SHBG and metabolic syndrome: After multivariable adjustment for age, BMI, current smoking and drinking status, physical activity level, SBP, TG, eGFR, γ-GGT, HbA1c, LDL-C, and HOMA-IR (Model 3), the OR[CI] of incident MetS for Quartile 1 was 2.33[1.13–4.79] (p<0.05), which suggests that lower SHBG might be considered as a predictor of new-onset MetS and its progression.