In a small study of 7 boys with CPP treated with GnRHa for 5,6 years (mean), pubertal response of FSH/LH to GnRH test was noted within 1,5 years and spermarche 0,7 to 3 years after cessation of GnRHa (with normal semen analysis) (67). The gene discussed is PLOD1; the disease is central precocious puberty.