Consequently, this disruption in BDNF signaling, as influenced by rs6265, is implicated in contributing to a spectrum of diseases, encompassing obesity and metabolic syndrome, cardiovascular health, cancer, as well as neurological and psychiatric disorders, all of which share similarities with the pathology observed in cases of aberrant BDNF expression. The gene discussed is BDNF; the disease is obesity due to melanocortin 4 receptor deficiency.