SNCA and Lewy body dementia: Some studies have shown reduced blood flow and hypometabolism within the DLB PVC, accompanied by indicators of reduced GABAergic activity, despite a lack of α-synuclein or neurofibrillary tangle pathology (Khundakar et al., 2016); such hypometabolism has also been observed to correlate with clinical features of DLB, regardless of the presence of cognitive decline.