Furthermore, as with PDD, DLB and AD share some neuropathological similarities; although deposits of misfolded tau and amyloid-β are the neuropathological hallmarks of AD, they are also observed in a high percentage of post-mortem DLB brains (Irwin et al., 2017), and α-synuclein inclusions can even be observed in many cases of AD (Twohig and Nielsen, 2019). Here, MAPT is linked to Alzheimer disease.