IL1RN and schizophrenia: IL-1RA protein, upon binding to IL-1R1 and IL-1R1+IL-1RAP, inhibits the binding of IL-1 and, consequently, theactivation of the IL-1 signaling pathway (Weber et al., 2010).In schizophrenia, the appearance of a single nucleotide polymorphismin the IL-1RA gene (p.Ser130Arg) may lead to theformation of a weakened complex between IL-1RA and associatedreceptors IL-1R1+IL-1RAP.