TNC and central nervous system cancer: TNC gene expression is upregulated during embryogenesis, inflammation-derived pathologies, and oncology (50) In the brain tissues of adults, the expression of TNC is usually low, while neurogenesis-associated regions, such as SVZ (subventricular zone) and SGZ (subgranular zone), where neural stem cells are localized, are characterized by elevated TNC. Overexpression of TNC was detected in malignancies including gliomas.