IL6 and type 2 diabetes mellitus: The insufficient glucose supply in the brain of T2DM could activate the glia, resulting in persistent neuroinflammation through various ways [12], which was supported by the findings in our previous studies that both microglial and astrocyte were activated in the hippocampus of rat injected with STZ, together with an enhanced abundance of inflammatory cytokines including IL-1β, Interleukin 6 (IL-6), and TNF-α [13].