In podocytes, one of the downstream genes of miR-215-5p was ZEB2, a key regulator of epithelial-mesenchymal transition, suggesting that ADSC-derived exosomal miR-215-5p might relieve podocyte injury by regulating ZEB2 expression and that ADSC-derived exosomal miRNAs have potential as therapeutic agents for obesity-related diabetic nephropathy and other kidney diseases [48]. This evidence concerns the gene ZEB2 and obesity due to melanocortin 4 receptor deficiency.