Antiphospholipid syndrome (APS) is a rare acquired autoimmune disease characterized by recurrent thrombosis and/or pregnancy complications, with the persistent existence of one or more antiphospholipid antibodies (aPLs), including lupus anticoagulant (LAC), anticardiolipin antibody (aCL), and anti-β2glycoprotein antibody (aβ2GPI) (1, 2). The gene discussed is ACLY; the disease is Venous thrombosis.