In addition, a significantly negative association with the risk of AF was observed in CD40l receptor levels (OR: 0.93; 95% CI: 0.89–0.97; P_adjust = 0.03; P_intercept = 0.74; P_mr−presso = 0.96; P_heterogeneity = 0.97) and leukemia inhibitory factor receptor levels (OR: 0.86; 95% CI: 0.80–0.91; P_adjust < 0.001). The gene discussed is CD40; the disease is atrial fibrillation.